SNARE Complex Formation Is Triggered by Ca2+ and Drives Membrane Fusion

@article{Chen1999SNARECF,
  title={SNARE Complex Formation Is Triggered by Ca2+ and Drives Membrane Fusion},
  author={Yu Alice Chen and Suzie J Scales and Sejal M. Patel and Y C Doung and Richard H. Scheller},
  journal={Cell},
  year={1999},
  volume={97},
  pages={165-174}
}
Neurotransmitter exocytosis, a process mediated by a core complex of syntaxin, SNAP-25, and VAMP (SNAREs), is inhibited by SNARE-cleaving neurotoxins. Botulinum neurotoxin E inhibition of norepinephrine release in permeabilized PC12 cells can be rescued by adding a 65 aa C-terminal fragment of SNAP-25 (S25-C). Mutations along the hydrophobic face of the S25-C helix result in SNARE complexes with different thermostabilities, and these mutants rescue exocytosis to different extents. Rescue… CONTINUE READING
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