SNAP-25 reduction in the hippocampus of patients with schizophrenia

@article{Thompson2003SNAP25RI,
  title={SNAP-25 reduction in the hippocampus of patients with schizophrenia},
  author={Peter M. Thompson and Shirley Egbufoama and Marquis P. Vawter},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2003},
  volume={27},
  pages={411-417}
}
In this study, the authors sought to replicate the findings of reduced synaptosomal associated protein 25 kDa (SNAP-25) immunoreactivity in the hippocampus of patients with schizophrenia. The authors also measured N-methyl-D-aspartate (NMDA) receptor 1 (NR1) receptor subunit to determine if glutamatergic synapses were involved with the loss of SNAP-25. We found 49% less SNAP-25 immunointensity in the schizophrenic group (n=7) compared to the control (n=8) or bipolar groups (n=4) (P=.004). There… Expand
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