SNAP-25 is required for a late postdocking step in Ca2+-dependent exocytosis.

@article{Banerjee1996SNAP25IR,
  title={SNAP-25 is required for a late postdocking step in Ca2+-dependent exocytosis.},
  author={Amiya K. Banerjee and Judith A. Kowalchyk and Bibhuti R. Dasgupta and Thomas F J Martin},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 34},
  pages={
          20227-30
        }
}
The Ca2+-activated fusion of large dense core vesicles (LDCVs) with the plasma membrane is reconstituted in mechanically permeabilized PC12 cells by provision of millimolar MgATP and cytosolic proteins. Ca2+-activated LDCV exocytosis was inhibited completely by the type E but not the type A botulinum neurotoxin (BoNT) even though both BoNTs were equally effective in proteolytically cleaving the synaptosome-associated protein of 25 kDa (SNAP-25). The greater inhibition of exocytosis by BoNT E… CONTINUE READING

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