SNAP-25 in neuropsychiatric disorders.

  title={SNAP-25 in neuropsychiatric disorders.},
  author={Irene Corradini and Claudia Verderio and Mariaelvina Sala and Michael C. Wilson and Michela Matteoli},
  journal={Annals of the New York Academy of Sciences},
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic… CONTINUE READING


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