SNAP-25 in hippocampal CA3 region is required for long-term memory formation.

  title={SNAP-25 in hippocampal CA3 region is required for long-term memory formation.},
  author={Qiu-Ling Hou and Xiang Gao and Q M Lu and Xue-han Zhang and Yan-yang Tu and Mei-lei Jin and Guo-Ping Zhao and Lei Yu and Nai-he Jing and Baoming Li},
  journal={Biochemical and biophysical research communications},
  volume={347 4},
SNAP-25 is a synaptosomal protein of 25 kDa, a key component of synaptic vesicle-docking/fusion machinery, and plays a critical role in exocytosis and neurotransmitter release. We previously reported that SNAP-25 in the hippocampal CA1 region is involved in consolidation of contextual fear memory and water-maze spatial memory (Hou et al. European J Neuroscience, 20: 1593-1603, 2004). SNAP-25 is expressed not only in the CA1 region, but also in the CA3 region, and the SNAP-25 mRNA level in the… CONTINUE READING
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