SNAP-25 in Major Psychiatric Disorders: A Review

  title={SNAP-25 in Major Psychiatric Disorders: A Review},
  author={Katherine Najera and B. Matthew Fagan and Peter M. Thompson},
Synaptosomal Associated Protein-25 kilodaltons (SNAP-25) is an integral member of the SNARE complex. This complex is essential for calcium-triggered synaptic vesicular fusion and release of neurotransmitters into the synaptic cleft. In addition to neurotransmission, SNAP-25 is associated with insulin release, the regulation of intracellular calcium, and neuroplasticity. Because of SNAP-25's varied and crucial biological roles, the consequences of changes in this protein can be seen in both the… Expand
Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample
It is found that select (but not all) proteoforms are strongly associated with cognitive function and the burden of Alzheimer’s disease (AD) pathology, and select presynaptic proteins are key in maintaining brain reserve. Expand
Genetic neuroimaging of bipolar disorder: a systematic 2017-2020 update.
It is concluded that there is no replicated finding in the timeframe considered and the most consistent finding is an influence of the CACNA1C rs1006737 polymorphism in brain connectivity and grey matter structure and function. Expand
Urinary proteome profiling for children with autism using data-independent acquisition proteomics.
The urinary proteome could distinguish between autistic children and non-autistic children and will provide a promising approach for future biomarker research of neuropsychiatric disorders. Expand
Dynamic Changes of Brain Cilia Transcriptomes across the Human Lifespan
A role for the high dynamics of cilia structural and functional components across the lifespan in the normal physiology of brain circuits is supported and suggest a crucial role for cilia signaling in the pathophysiological mechanisms of age-related psychiatric/neurological disorders. Expand
Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment
The hypothesis of a role for SNAP-25 in sarcopenia is supported and SNAP- 25-associated miRNAs are suggested as circulatory biomarkers of rehabilitative outcome for sarc Openia. Expand
Genetic control of variability in subcortical and intracranial volumes
A novel methodology is applied to perform genome-wide association analysis of mean and variance in ten key brain features, integrating genetic and neuroanatomical data from a large lifespan sample, and identifies genetic loci associated with phenotypic variability in thalamus volume and cortical thickness. Expand
Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease
  • Yu-Chi Huang, Chih-Hui Chang, +7 authors Cheng-Sheng Chen
  • Medicine
  • International journal of environmental research and public health
  • 2021
Preoperative recognition of major psychiatric disorders for risk and treatment assessment is suggested as people with preexisting depression or bipolar disorder have worse outcomes after spine surgery. Expand
Genetic control of variability in subcortical and intracranial volumes
It is identified that genetic loci associated with phenotypic variability in key brain structures: amygdala, pallidum, and intracranial volumes are associated with variation-controlling loci. Expand
Algo más que monoaminas en el tratamiento de la depresión: Mecanismos neurobiológicos emergentes de los antidepresivos del siglo XXI
New pathophysiological mechanisms involved in depression as targets for the search for different antidepressants are analyzed and disappointing results are reported in the field of endocrinology. Expand


SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population.
The results indicated that SNPs in SNAP25 represented a common risk factor of both schizophrenia and major depressive disorder in the Han Chinese population, and shared genetic variants have been demonstrated in 5 major psychiatric disorders. Expand
SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
This review summarizes recent work showing that SNAP-25 not only controls exo/endocytic processes at the presynaptic terminal, but also regulates postsynaptic receptor trafficking, spine morphogenesis, and plasticity, thus opening the possibility that Snap-25 defects may contribute to psychiatric diseases by impacting not only Presynaptic but also post synaptic functions. Expand
Region and diagnosis-specific changes in synaptic proteins in schizophrenia and bipolar I disorder
The data support the notion that there are complex and region-specific alterations in presynaptic proteins that may lead to alterations in synaptic activity in both schizophrenia and bipolar disorder. Expand
Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder.
Changes in SNAP-25 and synaptophysin in BPDI suggest that changes in specific neuronal functions could be linked to the pathology of the disorder. Expand
SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.
The finding that polymorphisms of the SNAP-25 gene, a gene involved in neurotransmission and regulation of calcium homeostasis, are associated with the degree of hyperactivity in children with ASD, reinforces the hypothesis that alterations of these mechanisms play a pivotal role in the events leading to ASD-associated behavioral impairment. Expand
Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population
Using HHRR and TDT, a large number of ADHD nuclear families from Ireland were analysed and found increased preferential transmission of SNAP-25/DdeI allelel to ADHD cases, but it is not clear what the role ofSNAP-25 in ADHD is. Expand
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Results indicate that reduction of SNAP-25 expression is associated to generation of epileptiform discharges and cognitive dysfunctions, which can be effectively treated by antiepileptic drugs. Expand
Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness.
In both groups with suicide as a cause of death, relatively more SNAP-25 and syntaxin was present in the heterotrimeric SNARE complex than in other molecular forms, which could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders. Expand
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis
An unexpected role of SNAP-25 is demonstrated in controlling PSD-95 clustering and the possibility that genetic reductions of the protein levels – as occurring in schizophrenia – may contribute to the pathology through an effect on postsynaptic function and plasticity is opened. Expand
Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down Syndrome and Alzheimer's disease
Findings of increased GFAP, a marker for neuronal loss, along with data from literature would support the notion of decreased snap‐25 secondary to neuronal decay in both neurodegenerative disorders. Expand