SNAP-25 Modulation of Calcium Dynamics Underlies Differences in GABAergic and Glutamatergic Responsiveness to Depolarization

@article{Verderio2004SNAP25MO,
  title={SNAP-25 Modulation of Calcium Dynamics Underlies Differences in GABAergic and Glutamatergic Responsiveness to Depolarization},
  author={Claudia Verderio and Davide Pozzi and Elena Pravettoni and Francesca Inverardi and Ursula Schenk and Silvia Coco and V{\'e}ronique Proux-Gillardeaux and T. Galli and Ornella Rossetto and Carolina Frassoni and Michela Matteoli},
  journal={Neuron},
  year={2004},
  volume={41},
  pages={599-610}
}
SNAP-25 is a component of the SNARE complex implicated in synaptic vesicle exocytosis. In this study, we demonstrate that hippocampal GABAergic synapses, both in culture and in brain, lack SNAP-25 and are resistant to the action of botulinum toxins type A and E, which cleave this SNARE protein. Relative to glutamatergic neurons, which express SNAP-25, GABAergic cells were characterized by a higher calcium responsiveness to depolarization. Exogenous expression of SNAP-25 in GABAergic… Expand
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