SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion.

@article{Sadoul1997SNAP23IN,
  title={SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion.},
  author={Karin Sadoul and Alexander C. Berger and Heiner Niemann and Ulrich Weller and Paul A. Roche and Amira Klip and William S. Trimble and Romano Regazzi and Stefano Catsicas and Philippe A. Halban},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 52},
  pages={
          33023-7
        }
}
The synaptosomal-associated protein of 25 kDa (SNAP-25) is expressed in neurons and endocrine cells. It has been shown to play an important role in the release mechanism of neurotransmitters and peptide hormones, including insulin. Thus, when insulin-secreting cells are permeabilized and treated with botulinum neurotoxin E (BoNT/E), SNAP-25 is hydrolyzed, and insulin secretion is inhibited. Recently SNAP-23, a more generally expressed isoform of SNAP-25, has been described. The functional role… CONTINUE READING

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