SNAP-23 is a target for calpain cleavage in activated platelets.

@article{Rutledge2002SNAP23IA,
  title={SNAP-23 is a target for calpain cleavage in activated platelets.},
  author={Tara W Rutledge and Sidney W Whiteheart},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 40},
  pages={
          37009-15
        }
}
The role of calpain in platelet function is generally associated with aggregation and clot retraction. In this report, data are presented to show that one component of the platelet secretory machinery, SNAP-23, is specifically cleaved by calpain in activated cells. Other proteins of the membrane fusion machinery, e.g. syntaxins 2 and 4 and alpha-SNAP, are not affected. In vitro studies, using permeabilized platelets, demonstrate that cleavage is time- and calcium-dependent. Analysis of SNAP-23… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Inhibition of calpain but not caspase activity by spectrin fragments

  • Cellular & Molecular Biology Letters
  • 2010
VIEW 1 EXCERPT
CITES BACKGROUND