SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription.

@article{Liu2013SMYD3AA,
  title={SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription.},
  author={Cheng Liu and Chang Wang and Kun Wang and Li Liu and Qi Shen and Keqiang Yan and Xiaoqing Sun and Jie Chen and Jikai Liu and Hongbo Ren and Hainan Liu and Zhonghua Xu and Sanyuan Hu and Dawei Xu and Yidong Fan},
  journal={Journal of the National Cancer Institute},
  year={2013},
  volume={105 22},
  pages={1719-28}
}
BACKGROUND Androgen receptor (AR) is critical for prostate tumorigenesis and is frequently overexpressed during prostate cancer (PC) progression. However, few studies have addressed the epigenetic regulation of AR expression. METHODS We analyzed SMYD3 expression in human PC with Western blot and immunohistochemistry. SMYD3 expression was knocked down using short hairpin RNA (shRNA) or small interfering RNA (siRNA). Cell proliferation, colony formation, and apoptosis analyses and xenograft… CONTINUE READING

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