SMR-type multidrug resistance pumps.

  title={SMR-type multidrug resistance pumps.},
  author={Yong Joon Chung and Milton H. Saier},
  journal={Current opinion in drug discovery & development},
  volume={4 2},
Multidrug resistance (MDR) efflux pumps in pathogenic microorganisms nullify the effects of antimicrobial drugs used in medicine. We have conducted phylogenetic analyses showing that these efflux pumps are associated with five superfamilies of transport systems. One of these, the drug/metabolite transporter (DMT) superfamily includes a family of small multidrug resistance (SMR)-conferring proteins that are discussed in detail in this review. A single microorganism such as Bacillus subtilis may… CONTINUE READING

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