SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania.

@article{Tull2004SMP1AM,
  title={SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania.},
  author={Dedreia L Tull and James Edward Vince and Judy M. Callaghan and Thomas Naderer and Tim P Spurck and Geoffrey Ian McFadden and Graeme P. Currie and Kris L Ferguson and Antony Bacic and Malcolm J. McConville},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 11},
  pages={
          4775-86
        }
}
The mechanisms by which proteins are targeted to the membrane of eukaryotic flagella and cilia are largely uncharacterized. We have identified a new family of small myristoylated proteins (SMPs) that are present in Leishmania spp and related trypanosomatid parasites. One of these proteins, termed SMP-1, is targeted to the Leishmania flagellum. SMP-1 is myristoylated and palmitoylated in vivo, and mutation of Gly-2 and Cys-3 residues showed that both fatty acids are required for flagellar… CONTINUE READING

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