SMN interacts with a novel family of hnRNP and spliceosomal proteins.

@article{Mourelatos2001SMNIW,
  title={SMN interacts with a novel family of hnRNP and spliceosomal proteins.},
  author={Zissimos Mourelatos and Linda Abel and Jeongsik Yong and Naoyuki Kataoka and Gideon Dreyfuss},
  journal={The EMBO journal},
  year={2001},
  volume={20 19},
  pages={5443-52}
}
Spinal muscular atrophy (SMA) is a common neurodegenerative disease caused by deletion or loss-of-function mutations of the survival of motor neurons (SMN) protein. SMN is in a complex with several proteins, including Gemin2, Gemin3 and Gemin4, and it plays important roles in small nuclear ribonucleoprotein (snRNP) biogenesis and in pre-mRNA splicing. Here, we characterize three new hnRNP proteins, collectively referred to as hnRNP Qs, which are derived from alternative splicing of a single… CONTINUE READING
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