SMN Tudor domain structure and its interaction with the Sm proteins

  title={SMN Tudor domain structure and its interaction with the Sm proteins},
  author={Philipp Selenko and Remco Sprangers and Gunter Stier and Dirk Michael B{\"u}hler and Utz Fischer and Michael Sattler},
  journal={Nature Structural Biology},
Spinal muscular atrophy (SMA) is a common motor neuron disease that results from mutations in the Survival of Motor Neuron (SMN) gene. The SMN protein plays a crucial role in the assembly of spliceosomal uridine-rich small nuclear ribonucleoprotein (U snRNP) complexes via binding to the spliceosomal Sm core proteins. SMN contains a central Tudor domain that facilitates the SMN–Sm protein interaction. A SMA-causing point mutation (E134K) within the SMN Tudor domain prevents Sm binding. Here, we… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 127 extracted citations

Similar Papers

Loading similar papers…