SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals

@inproceedings{TorresBenito2011SMNRF,
  title={SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals},
  author={Laura Torres-Benito and Margret Feodora Maria Neher and Raquel P{\'e}rez Cano and Rocio Ruiz and Luc{\'i}a Tabares},
  booktitle={PloS one},
  year={2011}
}
Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease in infants characterized by muscle weakness and impaired synaptic transmission. We report here severe structural and functional alterations in the organization of the organelles and the cytoskeleton of motor nerve terminals in a mouse model of SMA. The decrease in SMN levels resulted in the clustering of synaptic vesicles (SVs) and Active Zones (AZs), reduction in the size… CONTINUE READING

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