SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.

@article{Shaldubina2006SMIT1HC,
  title={SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.},
  author={Alona Shaldubina and Roy A Johanson and W. Timothy O'Brien and Roberto Buccafusca and Galila Agam and Robert Haim Belmaker and Peter G. Klein and Yuly Bersudsky and Gerard Thomas Berry},
  journal={Molecular genetics and metabolism},
  year={2006},
  volume={88 4},
  pages={384-8}
}
Two leading hypotheses to explain lithium action in bipolar disorder propose either inositol depletion or inhibition of GSK-3 as mechanisms of action. Behavioral effects of lithium are mimicked in Gsk-3beta+/- mice, but the contribution of inositol depletion to these behaviors has not been tested. According to the inositol depletion hypothesis, lithium-sensitive behavior is secondary to impaired phosphatidylinositol synthesis caused by inositol deficiency. By disrupting the sodium myo-inositol… CONTINUE READING

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