SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.

@article{Unterholzner2004SMG7AA,
  title={SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.},
  author={Leonie Unterholzner and Elisa Izaurralde},
  journal={Molecular cell},
  year={2004},
  volume={16 4},
  pages={
          587-96
        }
}
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that eliminates mRNAs containing premature termination codons (PTCs). The proteins UPF1, SMG5, SMG6, and SMG7 are essential NMD factors in metazoa. SMG5 and SMG7 form a complex with UPF1 and interact with each other via their N-terminal domains. Here we show that SMG5 and SMG7 colocalize in cytoplasmic mRNA decay bodies, while SMG6 forms separate cytoplasmic foci. When SMG7 is tethered to a reporter transcript, it elicits its… CONTINUE READING

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