SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

@article{Yamashita2009SMG8AS,
  title={SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.},
  author={Akio Yamashita and Natsuko Izumi and Isao Kashima and Tetsuo Ohnishi and Bonnie Saari and Yukiko Katsuhata and Reiko Muramatsu and Tomoko Morita and Akihiro Iwamatsu and Takahisa Hachiya and Rie Kurata and Hisashi Hirano and Philip Anderson and Shigeo Ohno},
  journal={Genes & development},
  year={2009},
  volume={23 9},
  pages={1091-105}
}
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades mRNAs containing premature translation termination codons (PTCs). SMG-1 and Upf1 transiently form a surveillance complex termed "SURF" that includes eRF1 and eRF3 on post-spliced mRNAs during recognition of PTC. If an exon junction complex (EJC) exists downstream from the SURF complex, SMG-1 phosphorylates Upf1, the step that is a rate-limiting for NMD. We provide evidence of an association between the SURF… CONTINUE READING
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