SMG 6 interacts with the exon junction complex via two conserved EJC-binding motifs ( EBMs ) required for nonsense-mediated mRNA decay

@inproceedings{Kashima2010SMG6I,
  title={SMG 6 interacts with the exon junction complex via two conserved EJC-binding motifs ( EBMs ) required for nonsense-mediated mRNA decay},
  author={Isao Kashima and Stefanie Jonas and Uma Jayachandran and Gretel Buchwald and Elena Conti and Andrei N. Lupas and Elisa Izaurralde},
  year={2010}
}
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades mRNAs containing premature stop codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Degradation of PTC-containing mRNAs requires the endonucleolytic activity of SMG6, a conserved NMD factor; nevertheless, the precise role for the EJC in NMD and how the SMG6 endonuclease is recruited to NMD targets have been unclear. Here we show that SMG6… CONTINUE READING

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