SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions

@article{TorresRosell2005SMC5AS,
  title={SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions},
  author={Jordi Torres-Rosell and F{\'e}lix Mach{\'i}n and Sarah L Farmer and A. Jarmuz and Trevor Eydmann and J. Z. Dalgaard and Lu{\'i}s Arag{\'o}n},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={412-419}
}
Structure chromosome (SMC) proteins organize the core of cohesin, condensin and Smc5–Smc6 complexes. The Smc5–Smc6 complex is required for DNA repair, as well as having another essential but enigmatic function. Here, we generated conditional mutants of SMC5 and SMC6 in budding yeast, in which the essential function was affected. We show that mutant smc5-6 and smc6-9 cells undergo an aberrant mitosis in which chromosome segregation of repetitive regions is impaired; this leads to DNA damage and… CONTINUE READING