SMC complexes: from DNA to chromosomes

  title={SMC complexes: from DNA to chromosomes},
  author={F. Uhlmann},
  journal={Nature Reviews Molecular Cell Biology},
  • F. Uhlmann
  • Published 2016
  • Chemistry, Medicine
  • Nature Reviews Molecular Cell Biology
  • SMC (structural maintenance of chromosomes) complexes — which include condensin, cohesin and the SMC5–SMC6 complex — are major components of chromosomes in all living organisms, from bacteria to humans. These ring-shaped protein machines, which are powered by ATP hydrolysis, topologically encircle DNA. With their ability to hold more than one strand of DNA together, SMC complexes control a plethora of chromosomal activities. Notable among these are chromosome condensation and sister chromatid… CONTINUE READING
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