SMARCAD1, a novel human helicase family-defining member associated with genetic instability: cloning, expression, and mapping to 4q22-q23, a band rich in breakpoints and deletion mutants involved in several human diseases.

@article{Adra2000SMARCAD1AN,
  title={SMARCAD1, a novel human helicase family-defining member associated with genetic instability: cloning, expression, and mapping to 4q22-q23, a band rich in breakpoints and deletion mutants involved in several human diseases.},
  author={Chaker N. Adra and Jos{\'e} Luis Donato and Rachel L Badovinac and Farhatullah Syed and R Kheraj and Hong Cai and Christopher Raymond Moran and Mitchell T Kolker and Hubert Turner and Stanislawa Weremowicz and Taro Shirakawa and Cynthia C Morton and Lowell E. Schnipper and Ruben Drews},
  journal={Genomics},
  year={2000},
  volume={69 2},
  pages={162-73}
}
Members of the DEAD/H box-containing helicase superfamily include proteins essential to genome replication, repair, and expression. We report here the cloning and initial characterization of a novel human member of this protein family, designated hHel1 (human helicase 1), now designated SMARCAD1 by HUGO. This DEAD/H box-containing molecule has seven highly conserved sequence regions that allow us to place it in the SNF2 family of the helicase superfamily. Uniquely, though, hHel1 contains two… CONTINUE READING
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