SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes.

@article{Skerlavaj1999SMAP29AP,
  title={SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes.},
  author={Barbara Skerlavaj and Monica Benincasa and Angela Risso and Margherita Zanetti and Renato Gennaro},
  journal={FEBS letters},
  year={1999},
  volume={463 1-2},
  pages={58-62}
}
SMAP-29 is a cathelicidin-derived peptide deduced from sheep myeloid mRNA. The C-terminally amidated form of this peptide was chemically synthesized and shown to exert a potent antimicrobial activity. Antibiotic-resistant clinical isolates highly susceptible to this peptide include MRSA and VREF isolates, that are a major worldwide problem, and mucoid Pseudomonas aeruginosa associated with chronic respiratory inflammation in CF patients. In addition, SMAP-29 is also active against fungi… CONTINUE READING

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