SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.

@article{Ozair2013SMAD7DC,
  title={SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.},
  author={Mohammad Zeeshan Ozair and Scott Noggle and Aryeh Warmflash and Joanna Ela Krzyspiak and Ali H. Brivanlou},
  journal={Stem cells},
  year={2013},
  volume={31 1},
  pages={35-47}
}
Human embryonic stem cells (hESCs) provide a valuable window into the dissection of the molecular circuitry underlying the early formation of the human forebrain. However, dissection of signaling events in forebrain development using current protocols is complicated by non-neural contamination and fluctuation of extrinsic influences. Here, we show that SMAD7, a cell-intrinsic inhibitor of transforming growth factor-β (TGFβ) signaling, is sufficient to directly convert pluripotent hESCs to an… CONTINUE READING
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