SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β.

@article{Crdova2015SMAD3AS,
  title={SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β.},
  author={Gonzalo J C{\'o}rdova and Alice Rochard and Camilo Riquelme-Guzm{\'a}n and Catalina Cofr{\'e} and Daniel Scherman and Pascal Bigey and Enrique Brandan},
  journal={Journal of cellular biochemistry},
  year={2015},
  volume={116 9},
  pages={1880-7}
}
Fibrotic disorders are characterized by an increase in extracellular matrix protein expression and deposition, Duchene Muscular Dystrophy being one of them. Among the factors that induce fibrosis are Transforming Growth Factor type β (TGF-β) and the matricellular protein Connective Tissue Growth Factor (CTGF/CCN2), the latter being a target of the TGF… CONTINUE READING