SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

Abstract

Secretory and endolysosomal fusion events are driven by SNAREs and cofactors, including Sec17/α-SNAP, Sec18/NSF, and Sec1/Munc18 (SM) proteins. SMs are essential for fusion in vivo, but the basis of this requirement is enigmatic. We now report that, in addition to their established roles as fusion accelerators, SM proteins Sly1 and Vps33 directly shield… (More)
DOI: 10.7554/eLife.02272

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Cite this paper

@inproceedings{Lobingier2014SMPS, title={SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18}, author={Braden T. Lobingier and Daniel Patrick Nickerson and Sheng-Ying Lo and Alexey J Merz}, booktitle={eLife}, year={2014} }