SLV330, a cannabinoid CB1 receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats

@article{Bruin2011SLV330AC,
  title={SLV330, a cannabinoid CB1 receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats},
  author={N. D. Bruin and J. H. M. Lange and C. Kruse and A. Herremans and T. Vries},
  journal={Behavioural Brain Research},
  year={2011},
  volume={217},
  pages={408-415}
}
  • N. D. Bruin, J. H. M. Lange, +2 authors T. Vries
  • Published 2011
  • Psychology, Medicine
  • Behavioural Brain Research
  • Cannabinoid CB(1) receptor (CB(1)R) signaling has been shown to play a role in the regulation of addictive behavior. In the present study, our aim was to investigate whether the CB(1)R antagonist SLV330 could reduce ethanol and nicotine self-administration and cue-induced reinstatement of ethanol and nicotine seeking behavior in Wistar rats. In operant chambers, rats were learned to emit a specific response (nose poke) in order to receive an ethanol solution or intravenous injections of… CONTINUE READING
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