SLV313 (1-(2,3-Dihydro-Benzo[1,4]Dioxin-5-yl)-4- [5-(4-Fluoro-Phenyl)-Pyridin-3-ylmethyl]-Piperazine Monohydrochloride): A Novel Dopamine D2 Receptor Antagonist and 5-HT1A Receptor Agonist Potential Antipsychotic Drug

@article{McCreary2007SLV313,
  title={SLV313 (1-(2,3-Dihydro-Benzo[1,4]Dioxin-5-yl)-4- [5-(4-Fluoro-Phenyl)-Pyridin-3-ylmethyl]-Piperazine Monohydrochloride): A Novel Dopamine D2 Receptor Antagonist and 5-HT1A Receptor Agonist Potential Antipsychotic Drug},
  author={Andrew C McCreary and Jeffrey Glennon and Charles R. Ashby and Herbert Y Meltzer and Zhu Li and J Reinders and Mayke B. Hesselink and Stephen Kenneth Long and Arnoud H J Herremans and Herman Heinrich van Stuivenberg and Rolf W Feenstra and Chris G. Kruse},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={78-94}
}
Combined dopamine D2 receptor antagonism and serotonin (5-HT)1A receptor agonism may improve efficacy and alleviate some side effects associated with classical antipsychotics. The present study describes the in vitro and in vivo characterization of 1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4-[5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride (SLV313), a D2/3 antagonist and 5-HT1A agonist. SLV313 possessed high affinity at human recombinant D2, D3, D4, 5-HT2B, and 5-HT1A receptors… CONTINUE READING

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SSR 181507 , a dopamine D ( 2 ) receptor antagonist and 5 - HT ( 1 A ) receptor agonist . I : Neurochemical and electrophysiological profile

  • Y Claustre, DD Peretti, P Brun, C Gueudet, N Allouard, R Alonso
  • Neuropsychopharmacology
  • 2003
Highly Influential
4 Excerpts

SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist

  • Y Claustre, DD Peretti, P Brun, C Gueudet, N Allouard, R Alonso
  • I: Neurochemical and electrophysiological profile…
  • 2003
Highly Influential
4 Excerpts

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