SLS1, a newSaccharomyces cerevisiae gene involved in mitochondrial metabolism, isolated as a syntheticlethal in association with anSSM4 deletion

SSM4 was isolated as a suppressor ofrna14-1, a mutant involved in nuclear mRNA maturation. In order to isolate genes interacting withSSM4, we have searched for mutants that are syntheticlethal in association with anSSM4 deletion. Among the mutants obtained, one, namedsls1-1, shows apet − phenotype. We have cloned and sequenced this gene. It encodes a… (More)