SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation.

@article{Clements1998SLP76EI,
  title={SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation.},
  author={James Lindsey Clements and Susan E. Ross-Barta and Lorraine T. Tygrett and Thomas J Waldschmidt and Gary A Koretzky},
  journal={Journal of immunology},
  year={1998},
  volume={161 8},
  pages={3880-9}
}
The leukocyte-specific adapter protein SLP-76 is known to augment the transcriptional activity of nuclear factor of activated T cells and AP-1 following TCR ligation. A role for SLP-76 in additional receptor-mediated signaling events is less clear. To define the pattern of SLP-76 expression during murine hemopoiesis, we stained cells isolated from various tissues with a combination of surface markers followed by intracellular staining with a fluorochrome-labeled SLP-76-specific Ab. In the bone… CONTINUE READING
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