SLP-76 couples Syk to the osteoclast cytoskeleton.

  title={SLP-76 couples Syk to the osteoclast cytoskeleton.},
  author={Jennifer L. Reeve and Wei Zou and Yuli Liu and Jonathan Scott Maltzman and Frederick Ross and Steven L Teitelbaum},
  journal={Journal of immunology},
  volume={183 3},
The capacity of the osteoclast (OC) to resorb bone is dictated by cytoskeletal organization, which in turn emanates from signals derived from the alpha(v)beta(3) integrin and c-Fms. Syk is key to these signals and, in other cells, this tyrosine kinase exerts its effects via intermediaries including the SLP adaptors, SLP-76 and BLNK (B cell linker). Thus, we… CONTINUE READING