SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.

@article{Cakmakci2008SLIP1AF,
  title={SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.},
  author={Nihal G Cakmakci and Rachel S. Lerner and Eric J. Wagner and Lianxing Zheng and William F Marzluff},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 3},
  pages={
          1182-94
        }
}
Replication-dependent histone mRNAs are the only eukaryotic cellular mRNAs that are not polyadenylated, ending instead in a conserved stem-loop. The 3' end of histone mRNA is required for histone mRNA translation, as is the stem-loop binding protein (SLBP), which binds the 3' end of histone mRNA. We have identified five conserved residues in a 15-amino-acid region in the amino-terminal portion of SLBP, each of which is required for translation. Using a yeast two-hybrid screen, we identified a… CONTINUE READING

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