SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.

@article{Tanaka2005SLIMIA,
  title={SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.},
  author={Takashi Tanaka and Michelle A. Soriano and M. J. Grusby},
  journal={Immunity},
  year={2005},
  volume={22 6},
  pages={729-36}
}
STAT proteins are a family of latent cytoplasmic transcription factors that are activated by tyrosine phosphorylation in response to a variety of cytokines, growth factors, and hormones. Once activated, STAT proteins translocate into the nucleus and help coordinate gene transcription. One striking feature of STAT signaling is its rapid and transient activation and deactivation cycle, although the molecular mechanisms responsible for this remain poorly understood. Here, we report on a nuclear… CONTINUE READING

From This Paper

Topics from this paper.
60 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Similar Papers

Loading similar papers…