SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission

@article{Wu2014SLEEPLESSIA,
  title={SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission},
  author={Meilin Wu and J Elliott Robinson and William J. Joiner},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={621-629}
}
BACKGROUND Although sleep is conserved throughout evolution, the molecular basis of its control is still largely a mystery. We previously showed that the quiver/sleepless (qvr/sss) gene encodes a membrane-tethered protein that is required for normal sleep in Drosophila. SLEEPLESS (SSS) protein functions, at least in part, by upregulating the levels and open probability of Shaker (Sh) potassium channels to suppress neuronal excitability and enable sleep. Consistent with this proposed mechanism… CONTINUE READING
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