SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study

  title={SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study},
  author={Jian-Quan Luo and Fa-zhong He and Zhen-Min Wang and Ning-ling Sun and Lu-yan Wang and Gen-fu Tang and Mou-Ze Liu and Qing Li and Xiaoping Chen and Zhaoqian Liu and Hong-hao Zhou and Wei Zhang},
  booktitle={Scientific reports},
Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups. Cough is the most common adverse reaction of enalapril. We investigate whether SLCO1B1 genetic polymorphisms, previously reported to be important determinants of inter-individual variability in enalapril pharmacokinetics, are associated with the enalapril-induced cough. A cohort of 450 patients with essential hypertension taking 10 mg… CONTINUE READING
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2014 update

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