SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

@inproceedings{Ahmadi2018SLC6A14AA,
  title={SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion},
  author={Saumel Ahmadi and Sunny Xia and Yu-Sheng Wu and Michelle Di Paola and Randolph Kissoon and Catherine Yuen Yee Luk and Fan Lin and Kai Li Du and Johanna M Rommens and Christine E Bear},
  booktitle={eLife},
  year={2018}
}
The severity of intestinal disease associated with Cystic Fibrosis (CF) is variable in the patient population and this variability is partially conferred by the influence of modifier genes. Genome-wide association studies have identified SLC6A14, an electrogenic amino acid transporter, as a genetic modifier of CF-associated meconium ileus. The purpose of the current work was to determine the biological role of Slc6a14, by disrupting its expression in CF mice bearing the major mutation, F508del… CONTINUE READING
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