SLC6 transporters: structure, function, regulation, disease association and therapeutics.

  title={SLC6 transporters: structure, function, regulation, disease association and therapeutics.},
  author={Akula Pramod and James Foster and Lucia Carvelli and L Keith Henry},
  journal={Molecular aspects of medicine},
  volume={34 2-3},
The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na(+)-dependent translocation of small amino acid or amino acid-like substrates. SLC6 transporters, which include the serotonin, dopamine, norepinephrine, GABA, taurine, creatine, as well as amino acid transporters, are associated with a number of human diseases and disorders making this family a critical target for therapeutic development. In addition, several members of this… CONTINUE READING
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