SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1

@inproceedings{Rebsamen2015SLC38A9IA,
  title={SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1},
  author={Manuele Rebsamen and Lorena Pochini and Taras Stasyk and Mariana E G de Araujo and Michele Galluccio and Richard Kumaran Kandasamy and Berend Snijder and Astrid Fauster and Elena L. Rudashevskaya and Manuela Bruckner and Stefania Scorzoni and Przemyslaw A Filipek and Kilian V M Huber and Johannes W Bigenzahn and Leonhard X. Heinz and Claudine Kraft and Keiryn L. Bennett and Cesare Indiveri and Lukas A. Huber and Giulio Superti-Furga},
  booktitle={Nature},
  year={2015}
}
Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose and amino acids to modulate metabolic status and cellular responses. mTORC1 is activated at the surface of lysosomes by the RAG GTPases and the Ragulator complex… CONTINUE READING