SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

@article{Vitart2008SLC2A9IA,
  title={SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout},
  author={Veronique Vitart and Igor Rudan and Caroline Hayward and Nicola K Gray and Jamie Floyd and Colin N. A. Palmer and Sara A. Knott and Ivana Kol{\vc}i{\'c} and Ozren Pola{\vs}ek and Juergen Graessler and James F. Wilson and Anthony Marin Marinaki and Philip L. Riches and Xinhua Shu and Branka Jani{\'c}ijevi{\'c} and Nina Smolej-Naran{\vc}i{\'c} and Barbara Gorgoni and Joanne Morgan and Susan Campbell and Zrinka Biloglav and Lovorka Barac-Lauc and Marijana Peri{\vc}i{\'c} and Irena Martinovi{\'c} Klari{\'c} and Lina Zgaga and Tatjana {\vS}kari{\'c}‐Juri{\'c} and Sarah H. Wild and William A. Richardson and Peter Hohenstein and Charley H Kimber and Albert Tenesa and Louise Donnelly and Lynette Fairbanks and Martin Aringer and Paul M. McKeigue and Stuart H. Ralston and Andrew D. Morris and Pavao Rudan and Nicholas D. Hastie and Harry Campbell and Alan F. Wright},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={437-442}
}
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 μM) compared with other mammals (3–120 μM). About 70% of daily urate disposal occurs via the kidneys, and in 5–25% of the human population, impaired renal excretion leads to hyperuricemia. About 10% of people with hyperuricemia develop gout, an inflammatory arthritis that results from deposition of monosodium urate… 
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SLC 2 A 9 ( GLUT 9 ) mediates urate reabsorption in the mouse kidney
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Results indicate that GLUT9 is a crucial player in renal handling of urate in vivo and a putative target for uricosuric drugs.
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