SLC25A51 is a mammalian mitochondrial NAD+ transporter.

  title={SLC25A51 is a mammalian mitochondrial NAD+ transporter.},
  author={T. Luongo and J. Eller and Mujie Lu and M. Niere and Fabio Raith and Caroline E Perry and Marc R Bornstein and Paul A. Oliphint and L. Wang and Melanie R McReynolds and M. Migaud and J. Rabinowitz and F. B. Johnson and K. Johnsson and M. Ziegler and Xiaolu A Cambronne and J. Baur},
  • T. Luongo, J. Eller, +14 authors J. Baur
  • Published 2020
  • Medicine
  • Nature
  • Mitochondria require nicotinamide adenine dinucleotide (NAD+) in order to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in yeast and plants1,2 but their very existence is controversial in mammals3-5. Here we demonstrate that mammalian mitochondria are capable of taking up intact NAD+ and identify SLC25A51 (an essential6,7 mitochondrial protein of previously unknown function, also known as… CONTINUE READING