SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.

@article{Lamason2005SLC24A5AP,
  title={SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.},
  author={Rebecca L. Lamason and Manzoor-Ali P.K Mohideen and Jason R Mest and Andrew Chiu-Yin Wong and Heather L. Norton and Michele C Aros and Michael J. Jurynec and Xianyun Mao and Vanessa R Humphreville and Jasper E. Humbert and Soniya Sinha and Jessica L. Moore and Pudur Jagadeeswaran and Wei Yi Zhao and Gang Min Ning and Izabela Makalowska and Paul M. McKeigue and David O'donnell and Rick A Kittles and Esteban J. Parra and Nancy J. Mangini and David Jonah Grunwald and Mark D. Shriver and Victor A Canfield and Keith C. Cheng},
  journal={Science},
  year={2005},
  volume={310 5755},
  pages={
          1782-6
        }
}
Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved… CONTINUE READING

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The corresponding uncorrected histograms

S fig.
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