SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans

  title={SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans},
  author={Rebecca L. Lamason and M. P. Mohideen and J. Mest and A. Wong and Heather L. Norton and M. Aros and M. J. Jurynec and X. Mao and Vanessa R Humphreville and Jasper E. Humbert and Soniya Sinha and J. L. Moore and P. Jagadeeswaran and W. Zhao and G. Ning and I. Makałowska and P. McKeigue and D. O'donnell and R. Kittles and E. Parra and Nancy J. Mangini and D. Grunwald and M. Shriver and V. Canfield and K. Cheng},
  pages={1782 - 1786}
  • Rebecca L. Lamason, M. P. Mohideen, +22 authors K. Cheng
  • Published 2005
  • Medicine, Biology
  • Science
  • Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved… CONTINUE READING
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