SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans

@article{Lamason2005SLC24A5AP,
  title={SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans},
  author={Rebecca L. Lamason and M. Mohideen and J. Mest and Andrew C Wong and Heather L. Norton and M. Aros and M. Jurynec and Xianyun Mao and Vanessa R Humphreville and Jasper E. Humbert and Soniya Sinha and Jessica L. Moore and P. Jagadeeswaran and W. Zhao and G. Ning and I. Makałowska and P. McKeigue and David O'donnell and R. Kittles and E. Parra and N. Mangini and D. Grunwald and M. Shriver and V. Canfield and K. Cheng},
  journal={Science},
  year={2005},
  volume={310},
  pages={1782 - 1786}
}
Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved… Expand
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