SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.

Abstract

Several studies have shown that melanin-concentrating hormone (MCH) is an orexigenic peptide in rat. In the present study, a structure-activity relationship with MCH analogs was performed in rat, both in vitro and in vivo. On rat recombinant SLC-1 receptor, both cAMP inhibition and [(125)I]S36057 binding were measured. In vivo, these analogs were injected… (More)

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Cite this paper

@article{Suply2001SLC1RM, title={SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.}, author={Thomas Suply and Odile Della Zuana and Val{\'e}rie Audinot and M. Rodriguez and Philippe Beauverger and Jacques L Duhault and Emmanuelle Canet and Jean Pierre Galizzi and J L Nahon and Neil Levens and Jean Boutin}, journal={The Journal of pharmacology and experimental therapeutics}, year={2001}, volume={299 1}, pages={137-46} }