SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.

@article{Cte2015SLATPT,
  title={SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.},
  author={Marjorie C{\^o}te and Camille Fos and Ann J. Canonigo-Balancio and Klaus Ley and St{\'e}phane B{\'e}cart and Amnon Altman},
  journal={Journal of cell science},
  year={2015},
  volume={128 23},
  pages={4341-52}
}
SLAT (also known as DEF6) promotes T cell activation and differentiation by regulating NFAT-Ca(2+) signaling. However, its role in TCR-mediated inside-out signaling, which induces integrin activation and T cell adhesion, a central process in T cell immunity and inflammation, has not been explored. Here, we show that SLAT is crucial for TCR-induced adhesion to ICAM-1 and affinity maturation of LFA-1 in CD4(+) T cells. Mechanistic studies revealed that SLAT interacts, through its PH domain, with… CONTINUE READING

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