SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.

@article{Peterson2011SLAPDE,
  title={SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.},
  author={Lisa Kay Peterson and Laura A. Shaw and Anthony Joetham and Shimon Sakaguchi and Erwin W. Gelfand and Leonard L Dragone},
  journal={Journal of immunology},
  year={2011},
  volume={186 4},
  pages={2273-81}
}
To test if manipulating TCR complex-mediated signaling (TCR signaling) could treat autoimmune disease, we generated the double SKG Src-like adapter protein (SLAP) knockout (DSSKO) mouse model. The SKG mutation in ZAP70 and SLAP have opposing functions on the regulation of TCR signaling. The combination of these two mutations alters TCR signaling in the context of a defined genetic background, uniform environmental conditions, and a well-characterized signaling disruption. In contrast to SKG… CONTINUE READING