SLAM (CDw150) is a cellular receptor for measles virus

@article{Tatsuo2000SLAMI,
  title={SLAM (CDw150) is a cellular receptor for measles virus},
  author={Hironobu Tatsuo and Nobuyuki Ono and Kotaro Tanaka and Yusuke Yanagi},
  journal={Nature},
  year={2000},
  volume={406},
  pages={893-897}
}
Measles virus continues to be a major killer of children, claiming roughly one million lives a year. Measles virus infection causes profound immunosuppression, which makes measles patients susceptible to secondary infections accounting for high morbidity and mortality. The Edmonston strain of measles virus, and vaccine strains derived from it, use as a cellular receptor human CD46 (refs 3, 4), which is expressed on all nucleated cells; however, most clinical isolates of measles virus cannot use… Expand
Measles virus receptor SLAM (CD150).
TLDR
This review is concerned with the identification of a new MV receptor and its implication for understanding the pathology and pathogenesis of MV infection. Expand
CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus.
TLDR
Methods used to identify and characterize this lymphocyte receptor for measles virus are described, and interaction of measles virus with CDw150(SLAM) could explain the immunosuppressive properties of this virus. Expand
The cellular receptor for measles virus—elusive no more
  • Y. Yanagi
  • Biology, Medicine
  • Reviews in medical virology
  • 2001
TLDR
It is shown that human signalling lymphocytic activation molecule (SLAM; also known as CDw150) is a cellular receptor for measles virus, including the Edmonston strain. Expand
CD147/EMMPRIN Acts as a Functional Entry Receptor for Measles Virus on Epithelial Cells
TLDR
This is the first report among members of the Mononegavirales that CD147 is used as a virus entry receptor via incorporated CypB in the virions, independently of MeV H. Expand
Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus
TLDR
It is demonstrated that wild type measles virus infects primary airway epithelial cells grown in fetal calf serum and many adenocarcinoma cell lines of the lung, breast, and colon and several strains of measles virus were shown to use PVRL4 as a receptor. Expand
CD150 (SLAM) Is a Receptor for Measles Virus but Is Not Involved in Viral Contact-Mediated Proliferation Inhibition
TLDR
The data indicate that proliferation inhibition induced by MV contact is independent of the presence or absence of the virus-binding receptors SLAM and CD46, and the cell-type-specific expression of SLAM does not correlate with the sensitivity of cells for proliferation inhibition. Expand
Morbilliviruses Use Signaling Lymphocyte Activation Molecules (CD150) as Cellular Receptors
TLDR
The findings suggest that the use of SLAM as a cellular receptor may be a property common to most, if not all, morbilliviruses and explain the lymphotropism and immunosuppressive nature of morbillIViruses. Expand
[Two different receptors for wild type measles virus].
TLDR
Nectin4, a cellular adhesion junction molecule, was identified as the epithelial cell receptor for MV and provides a deep insight into measles pathogenesis. Expand
Induction of the measles virus receptor SLAM (CD150) on monocytes.
TLDR
Anti-SLAM monoclonal antibodies efficiently blocked infection of activated monocytes with a wild-type strain of MV and indicate that SLAM is readily induced and acts as a monocyte receptor for MV. Expand
Measles Virus Infects both Polarized Epithelial and Immune Cells by Using Distinctive Receptor-Binding Sites on Its Hemagglutinin
TLDR
The results indicate that MV has an intrinsic ability to infect both polarized epithelial and immune cells by using distinctive receptor-binding sites on the attachment protein corresponding to each of their respective receptors. Expand
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References

SHOWING 1-10 OF 28 REFERENCES
The human CD46 molecule is a receptor for measles virus (Edmonston strain)
TLDR
Results prove that human CD46 permits cells both to bind measles virus and to support infection and polyclonal antisera against CD46 inhibited virus binding and infection. Expand
Clinical Isolates of Measles Virus Use CD46 as a Cellular Receptor
TLDR
The results indicate that patient isolates that have not been adapted to tissue culture cell lines use CD46 as a receptor, and confirm the relevance of the CD46 receptor to natural measles infection. Expand
Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus
TLDR
Results show that the human CD46 molecule serves as an MV receptor allowing virus-cell binding, fusion, and viral replication and open new perspectives in the study of MV pathogenesis. Expand
Marmoset lymphoblastoid cells as a sensitive host for isolation of measles virus
TLDR
It was suspected that measles virus is subject to host cell-mediated selection and that the viruses grown in B95a cells are more representative of measles virus circulating among humans than are the viruses selected in Vero cells. Expand
Receptor usage and differential downregulation of CD46 by measles virus wild-type and vaccine strains.
TLDR
It is found that the infection of human cell lines with all 19 MV strains tested was inhibitable with antibodies against CD46, and lymphotropic wild-type strains of MV which do not downregulate CD46 may have an advantage for replication in vivo. Expand
Experimental measles. I. Pathogenesis in the normal and the immunized host.
TLDR
Animals vaccinated with the attenuated Moraten strain did not develop clinical or pathologic signs of measles after challenge, but moderate to marked hyperplasia occurred in the lymph nodes and spleen of a vaccinated animal on Day 7 after pathogenic virus challenge, suggesting that an effective measles vaccine limits but does not prevent infection with wild-type measles virus. Expand
Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro.
TLDR
It is indicated that a small number of MV-infected PBLs can induce a general nonresponsiveness in uninfected P BLs by surface contact, which may, in turn, account for the general suppression of immune responses observed in patients with acute measles. Expand
A Single Amino Acid Change in the Hemagglutinin Protein of Measles Virus Determines Its Ability To Bind CD46 and Reveals Another Receptor on Marmoset B Cells
TLDR
Evidence for a measles virus receptor other than CD46 on transformed marmoset and human B cells is provided, through the use of a direct binding assay, that a second receptor for measles virus is present on primate B cells. Expand
Differential downregulation of CD46 by measles virus strains
TLDR
It is reported that neither the source of MV nor the cell type used for isolation directly influenced the capacity for CD46 modulation of these MV isolates. Expand
Virus Entry Is a Major Determinant of Cell Tropism of Edmonston and Wild-Type Strains of Measles Virus as Revealed by Vesicular Stomatitis Virus Pseudotypes Bearing Their Envelope Proteins
TLDR
The results indicate that the difference in cell tropism between these MV strains was largely determined by virus entry, in which the H proteins of respective MV strains play a decisive role. Expand
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