SLAM (CDw150) is a cellular receptor for measles virus

@article{Tatsuo2000SLAMI,
  title={SLAM (CDw150) is a cellular receptor for measles virus},
  author={Hironobu Tatsuo and Nobuyuki Ono and Kotaro Tanaka and Yusuke Yanagi},
  journal={Nature},
  year={2000},
  volume={406},
  pages={893-897}
}
Measles virus continues to be a major killer of children, claiming roughly one million lives a year. Measles virus infection causes profound immunosuppression, which makes measles patients susceptible to secondary infections accounting for high morbidity and mortality. The Edmonston strain of measles virus, and vaccine strains derived from it, use as a cellular receptor human CD46 (refs 3, 4), which is expressed on all nucleated cells; however, most clinical isolates of measles virus cannot use… 

Measles virus receptor SLAM (CD150).

TLDR
This review is concerned with the identification of a new MV receptor and its implication for understanding the pathology and pathogenesis of MV infection.

The cellular receptor for measles virus—elusive no more

  • Y. Yanagi
  • Biology
    Reviews in medical virology
  • 2001
TLDR
It is shown that human signalling lymphocytic activation molecule (SLAM; also known as CDw150) is a cellular receptor for measles virus, including the Edmonston strain.

CD147/EMMPRIN Acts as a Functional Entry Receptor for Measles Virus on Epithelial Cells

TLDR
This is the first report among members of the Mononegavirales that CD147 is used as a virus entry receptor via incorporated CypB in the virions, independently of MeV H.

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

TLDR
It is demonstrated that wild type measles virus infects primary airway epithelial cells grown in fetal calf serum and many adenocarcinoma cell lines of the lung, breast, and colon and several strains of measles virus were shown to use PVRL4 as a receptor.

CD150 (SLAM) Is a Receptor for Measles Virus but Is Not Involved in Viral Contact-Mediated Proliferation Inhibition

TLDR
The data indicate that proliferation inhibition induced by MV contact is independent of the presence or absence of the virus-binding receptors SLAM and CD46, and the cell-type-specific expression of SLAM does not correlate with the sensitivity of cells for proliferation inhibition.

Morbilliviruses Use Signaling Lymphocyte Activation Molecules (CD150) as Cellular Receptors

TLDR
The findings suggest that the use of SLAM as a cellular receptor may be a property common to most, if not all, morbilliviruses and explain the lymphotropism and immunosuppressive nature of morbillIViruses.

[Two different receptors for wild type measles virus].

TLDR
Nectin4, a cellular adhesion junction molecule, was identified as the epithelial cell receptor for MV and provides a deep insight into measles pathogenesis.

Induction of the measles virus receptor SLAM (CD150) on monocytes.

TLDR
Anti-SLAM monoclonal antibodies efficiently blocked infection of activated monocytes with a wild-type strain of MV and indicate that SLAM is readily induced and acts as a monocyte receptor for MV.

Measles Virus Infects both Polarized Epithelial and Immune Cells by Using Distinctive Receptor-Binding Sites on Its Hemagglutinin

TLDR
The results indicate that MV has an intrinsic ability to infect both polarized epithelial and immune cells by using distinctive receptor-binding sites on the attachment protein corresponding to each of their respective receptors.

Analysis of receptor (CD46, CD150) usage by measles virus.

TLDR
It is demonstrated that the single amino acid exchange in the haemagglutinin (H) protein at position 481 Asn/Tyr (H481NY) determines whether the virus can utilize CD46, and demonstrates that the binding sites for SLAM and CD46 are distinct.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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