SKI knockdown inhibits human melanoma tumor growth in vivo

@article{Chen2009SKIKI,
  title={SKI knockdown inhibits human melanoma tumor growth in vivo},
  author={Dahu Chen and Qiushi Lin and Neil Box and Dennis R. Roop and Shunsuke Ishii and Koichi Matsuzaki and Tao Fan and Thomas J. Hornyak and Jon A. Reed and Edward Stavnezer and Nikolai A. Timchenko and Estela E. Medrano},
  journal={Pigment Cell \& Melanoma Research},
  year={2009},
  volume={22}
}
  • Dahu Chen, Q. Lin, E. Medrano
  • Published 1 December 2009
  • Biology, Medicine, Chemistry
  • Pigment Cell & Melanoma Research
The SKI protein represses the TGF‐β tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant melanoma tumors in a disease‐progression manner and its overexpression promotes proliferation and migration of melanoma cells in vitro. The mechanisms by which SKI antagonizes TGF‐β signaling in vivo have not been fully elucidated. Here we show that human melanoma cells in which endogenous SKI expression was knocked down by RNAi produced minimal… 
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Title Efficient TGF-beta / SMAD signaling in human melanoma cells associated with high c-SKI / SnoN expression Permalink
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