Corpus ID: 27609445

SKI activates Wnt/beta-catenin signaling in human melanoma.

  title={SKI activates Wnt/beta-catenin signaling in human melanoma.},
  author={Dahu Chen and Wei-dong Xu and E. Bales and C. Colmenares and M. Conacci-Sorrell and S. Ishii and E. Stavnezer and J. Campisi and D. Fisher and A. Ben-Ze'ev and E. Medrano},
  journal={Cancer research},
  volume={63 20},
Overexpression of the oncoprotein SKI correlates with the progression of human melanoma in vivo. SKI is known to curtail the growth inhibitory activity of tumor growth factor beta through the formation of repressive transcriptional complexes with Smad2 and Smad3 at the p21(Waf-1) promoter. Here, we show that SKI also stimulates growth by activating the Wnt signaling pathway. From a yeast two-hybrid screen and immunoprecipitation studies, we identified the protein FHL2/DRAL as a novel SKI… Expand
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