SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells

@inproceedings{Liu2014SKIIIRT,
  title={SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells},
  author={Ying Liu and Zuan Zhu and Hongxing Cai and Qinghua Liu and Honglian Zhou and Zhengqiu Zhu},
  booktitle={Oncology letters},
  year={2014}
}
Cisplatin is frequently used in treating gastric cancers; however, acquired resistance to the drug often reduces the efficacy of therapy. The present study analyzed the efficacy of the combination of 4-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-phenol (SKI-II) and cisplatin [cis-diamminedichloroplatinum (II); DDP] on the gastric cancer SGC7901/DDP cell line. The results revealed that SKI-II and DDP had a clear synergistic effect. Glutathione (GSH) and glutathione S-transferase (GST) levels… CONTINUE READING

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