SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.

@article{Wang2008SKAP55SA,
  title={SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.},
  author={Hong-yan Wang and Christopher E. Rudd},
  journal={Trends in cell biology},
  year={2008},
  volume={18 10},
  pages={486-93}
}
Integrin adhesion is essential for aspects of immune function, including antigen presentation and migration in lymph nodes, germinal centers and sites of inflammation. Antigen receptors on B and T cells generate 'inside-out' signals for increased integrin clustering and adhesion. Although upstream components of B-cell-receptor or T-cell-receptor signaling are needed, the identity of key downstream effectors that mediate integrin adhesion is only just emerging. New candidates include immune-cell… CONTINUE READING
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